Covalent conjugation technologies allow for the modular assembly of complex proteins, enabling the production of bispecific antibodies at high combinatorial scales. The aim of the project is to derive a new peptide-protein conjugation technology that has beneficial features in generating novel bispecific antibodies.

You will work in collaboration with the biochemistry team to deliver this project. This will involve:

• Computational design and selection of protein modifications allowing covalent conjugation
• Use of high-throughput DNA cloning methodologies to produce plasmids for protein expression
• Optimising purification methods and perform biochemical and biophysical characterisation for protein constructs
• Suggest and implement novel ideas related to the project

You will work primarily on this project, but may be expected to perform other roles within the biochemistry team as required. By the end of the internship, you will be expected to be working independently taking the lead on project direction, generate accurate reports and give presentations to the team.

Required experience and skills

We are looking for candidates with:

• Experience in working with molecular biology techniques, particularly modern DNA cloning methodologies
• Experience in protein biochemistry, including recombinant protein expression and purification
• Motivation to challenge and learn new skills and knowledge

Not required but helpful attributes include:

• Experience in computational protein engineering using open-source bioinformatics tools, structural prediction software, such as AlphaFold, and molecular dynamics simulations.
• Experience in using an automated liquid handlers

Diversity and inclusion

Our science knows no boundaries and so does our employment criteria. We welcome applicants from any background without discrimination on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.